NewTuberculosisRegimenWorksFaster,CostsLess
PamHarrison
一种组合药物PaMZ由新的结核病候选药PA-mgorPA-mg、莫西沙星mg以及吡嗪酰胺mg组成。
早期阶段的研究表明，PaMZ方案治愈时间更短，更简单，更安全，且与现在的多重耐药性结核（MDR-TB）药物相比更加便宜。全球结核病药物研发联盟预计，PaMZ方案有望极大缩短治愈多重耐药性结核（MDR-TB）的时间，从2年时间缩短至短短6个月，同时将淘汰注射剂的使用，并可使MDR-TB治疗费用降低高达90%。此外，PaMZ方案有望与常用的HIV药物兼容，并帮助数以百万计的TB/HIV共感染者。
MELBOURNE,Australia—Aonce-dailyoralregimenknownasPaMZshowspromiseinbothdrug-sensitiveandmultidrug-resistanttuberculosis(TB),newresearchshows.
After8weeksoftreatment,morepatientstreatedwithPaMZthanwiththestandardTBprotocolwereculture-negative(71%vs38%),saidDanEveritt,MD,seniormedicalofficerattheGlobalAllianceforTBDrugDevelopment.
Thiscouldbeaparadigmchangeforshorteningandsimplifyingdrugtherapyfordrug-sensitiveanddrug-resistantTB,hesaid.Drug-resistantpatientstypicallyrequire5to7drugsgivenovera2-yearperiod,withdailyinjectionsadministeredinthefirst6months.
Dr.Everittpresentedthestudyresultshereatthe20thInternationalAIDSConference.
Thestudywasconductedat8sitesinSouthAfricaandTanzania.Theprimaryendpointwastherateofchangeincolony-formingunitsfromsputumonsolidcultureoveran8-weekperiod.
About20%ofthestudyparticipantswascoinfectedwithHIV.
Drug-sensitivepatientswererandomizedto1of2PaMZregimensorthestandardTBprotocol,consistingofisoniazid,rifampicin,pyrazinamide,andethambutol.
ThePaMZregimenconsistedofmoxifloxacinmgandpyrazinamidemg,plusPA-mgorPA-mg.
Alldrug-resistantpatientsreceivedthemgPaMZregimen.
InvestigatorsfoundthatthePaMZregimenhasactivebactericidalactivity.
Table.DailyReductionsinColony-FormingUnits
TreatmentGroups
ReductionPerDay
Drug-sensitivepatients
mgPaMZregimen
0.
mgPaMZregimen
0.
StandardTBprotocol
0.
Drug-resistantpatients
mgPaMZregimen
0.
MediantimetothefirstnegativeculturewassignificantlyshorterwiththemgPaMZregimenthanwiththestandardTBprotocol(28vs35days).
Thepercentageofgrade3and4adverseeventswassimilarinalltreatmentgroups.
Goingtoa4-monthregimenfordrug-sensitivepatientscutstheamountoftimeontherapyby30%,Dr.Everittsaid.Itishopedthatmorepatientswill北京治疗白癜风哪里医院疗效好复方木尼
